Exploring how certain vesicles can help improve memory loss in aging and Alzheimer’s disease.
Official title: Investigating a role for eNAMPT-containing extracellular vesicles in mitigating age- and Alzheimer Disease-related cognitive decline
Funded at Washington University · NIH-11059053 · Data updated 2026-11-12
This study is looking at how tiny particles in the body that carry a special protein might help improve memory and brain health for older adults and those with Alzheimer’s by boosting a key molecule that often decreases with age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $81,364 |
| NIH project number | 5F32AG076279-03 |
| Project ID | NIH-11059053 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing cognitive decline or individuals diagnosed with Alzheimer’s disease.
✕Less likely to help
Patients with cognitive impairments due to causes other than aging or Alzheimer’s disease may not benefit from this research.
What this research studies
This research investigates the role of extracellular vesicles containing a protein called eNAMPT in combating cognitive decline associated with aging and Alzheimer’s disease. The study aims to understand how these vesicles can restore levels of a crucial molecule, NAD+, which is often depleted in older adults and those with Alzheimer’s. By examining the effects of these vesicles on brain function in animal models, the research seeks to uncover potential new treatments for memory impairment. Patients may benefit from insights gained about how to enhance cognitive health as they age or in the context of Alzheimer’s.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function and quality of life for older adults and Alzheimer’s patients.
How similar studies have gone: Previous research has shown promising results with similar approaches using extracellular vesicles to enhance cognitive function, suggesting potential for success in this area.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Lananna, Brian Vincent — Washington University
- Study coordinator: Lananna, Brian Vincent
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.