Exploring how certain nutrients affect heart disease risk
Nutrition, terminal NAD metabolites and cardiovascular disease
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11070380
This study is looking at how certain substances related to vitamin B3 in your blood might affect your heart health and risk of heart disease, and it invites patients to share their blood samples and health info to help us learn more about this connection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11070380 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between specific metabolites linked to vitamin B3 and the risk of developing cardiovascular disease (CVD). By analyzing blood samples, the study aims to identify how these metabolites, particularly 4PY, influence vascular health and inflammation. The research combines nutritional data with metabolic analysis to understand how dietary factors and genetic variants may contribute to heart disease. Patients may be involved in providing blood samples and health information to help uncover these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for cardiovascular disease or those with a family history of heart conditions.
Not a fit: Patients who are not at risk for cardiovascular disease or do not have related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or treatments that reduce the risk of cardiovascular disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of metabolites in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAZEN, STANLEY L — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: HAZEN, STANLEY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.