Exploring how certain nutrients affect heart disease risk
Official title: Nutrition, terminal NAD metabolites and cardiovascular disease
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11070380 · Data updated 2026-11-12
This study is looking at how certain substances related to vitamin B3 in your blood might affect your heart health and risk of heart disease, and it invites patients to share their blood samples and health info to help us learn more about this connection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $705,896 |
| NIH project number | 5R01HL169290-02 |
| Project ID | NIH-11070380 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for cardiovascular disease or those with a family history of heart conditions.
✕Less likely to help
Patients who are not at risk for cardiovascular disease or do not have related health concerns may not benefit from this research.
What this research studies
This research investigates the relationship between specific metabolites linked to vitamin B3 and the risk of developing cardiovascular disease (CVD). By analyzing blood samples, the study aims to identify how these metabolites, particularly 4PY, influence vascular health and inflammation. The research combines nutritional data with metabolic analysis to understand how dietary factors and genetic variants may contribute to heart disease. Patients may be involved in providing blood samples and health information to help uncover these connections.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or treatments that reduce the risk of cardiovascular disease.
How similar studies have gone: Previous research has shown promising results in understanding the role of metabolites in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Hazen, Stanley L — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Hazen, Stanley L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.