Exploring how certain kidney cancer cells change and spread
Official title: Investigation of the role of epithelial-mesenchymal plasticity in renal cell carcinoma
Funded at University of Tx Md Anderson Can Ctr · NIH-11061417 · Data updated 2026-11-12
This study is looking at a tough type of kidney cancer called sarcomatoid renal cell carcinoma to find out how certain changes in the cancer cells might help it grow and spread, with the goal of discovering new treatment options that could work better for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $630,665 |
| NIH project number | 5R01CA258226-05 |
| Project ID | NIH-11061417 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with sarcomatoid renal cell carcinoma who are seeking new treatment options.
✕Less likely to help
Patients with other types of kidney cancer or those who do not have sarcomatoid features may not benefit from this research.
What this research studies
This research investigates sarcomatoid renal cell carcinoma (sRCC), a type of kidney cancer known for its aggressive nature and resistance to standard treatments. The study aims to understand the role of epithelial-mesenchymal plasticity (EMT) in the progression and metastasis of this cancer. By analyzing the genomic and molecular changes in these tumors, researchers hope to identify specific vulnerabilities that could lead to more effective therapies. Patients may benefit from insights that could improve treatment strategies and outcomes for this challenging cancer.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve outcomes for patients with sarcomatoid renal cell carcinoma.
How similar studies have gone: While there has been significant research into various aspects of kidney cancer, the specific focus on epithelial-mesenchymal plasticity in sarcomatoid renal cell carcinoma is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Genovese, Giannicola — University of Tx Md Anderson Can Ctr
- Study coordinator: Genovese, Giannicola
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.