Exploring how certain immune molecules in sharks relate to human immune function
Determining the Origins of Nonclassical Class I molecules through Molecular and Functional Approaches
This study is looking at special immune molecules in sharks to learn how they work and how they might help us understand our own immune systems better, which could lead to new health benefits for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11089386 on NIH RePORTER |
What this research studies
This research investigates the origins and functions of nonclassical class I molecules in sharks, which are ancient vertebrates with unique immune systems. The study focuses on two specific shark molecules, UFA and UDA, that show similarities to human immune molecules. By using advanced techniques such as structural modeling and biochemical analysis, researchers aim to understand how these molecules interact with immune cells. This could provide insights into adaptive immunity and potential applications in human health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with immune system disorders or those interested in advancements in immunotherapy.
Not a fit: Patients with conditions unrelated to immune system function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses and lead to new therapeutic strategies for immune-related diseases in humans.
How similar studies have performed: Other research has shown promising results in understanding immune mechanisms through comparative studies of different species, suggesting potential for success in this novel approach.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Flajnik, Martin F — University of Maryland Baltimore
- Study coordinator: Flajnik, Martin F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.