Exploring how certain immune cells affect tuberculosis
Understanding the functional role of Myeloid Derived Suppressor cells in tuberculosis
['FUNDING_R01'] · UNIVERSITY OF CHICAGO · NIH-10653128
This study is looking at how certain immune cells called Myeloid Derived Suppressor Cells (MDSCs) affect the body's fight against tuberculosis, with the hope of finding new ways to boost treatments and vaccines for people with this disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10653128 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Myeloid Derived Suppressor Cells (MDSCs) in tuberculosis, a disease caused by Mycobacterium tuberculosis. The study aims to understand how these immune cells influence the body's ability to control the infection, particularly in the context of granulomas, which are clusters of immune cells that form in response to the bacteria. By examining the interactions between MDSCs and T cells, the research seeks to identify potential targets for improving immune responses against tuberculosis. The findings could lead to new strategies for enhancing the effectiveness of existing treatments and vaccines.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculosis, particularly those with drug-resistant strains or those experiencing severe disease.
Not a fit: Patients with non-infectious respiratory conditions or those who have not been diagnosed with tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and vaccines for tuberculosis, potentially saving lives and reducing disease transmission.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in tuberculosis, but the specific role of MDSCs in this context is still being explored.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHADER, SHABAANA A. — UNIVERSITY OF CHICAGO
- Study coordinator: KHADER, SHABAANA A.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.