Exploring how certain genes are controlled by their location in the cell nucleus
Understanding mechanisms of heterochromatin tethering at the nuclear lamina
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11091426
This study is looking at how certain parts of our DNA are held in place within the cell's nucleus and how this affects gene activity, which could help us understand some genetic disorders better and find new ways to help patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11091426 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which specific regions of DNA, known as heterochromatin, are anchored to the nuclear lamina, a structure that helps organize the cell's nucleus. By studying how these regions are marked and maintained, the research aims to uncover the role of this anchoring in gene repression and cell function. The approach involves examining the interactions between lamina proteins and chromatin modifications to understand their impact on gene expression. Patients may benefit from insights into how disruptions in these processes can lead to various diseases, including genetic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or conditions related to abnormal gene expression, particularly those affected by laminopathies.
Not a fit: Patients with conditions unrelated to chromatin structure or gene expression regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to gene expression abnormalities.
How similar studies have performed: Previous research has shown that understanding chromatin dynamics and nuclear organization can lead to significant advancements in genetic disease treatment.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUCHWALTER, ABIGAIL LYNN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: BUCHWALTER, ABIGAIL LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.