Exploring how certain genes affect Alzheimer's disease
Official title: Uncovering the Role of the MS4A Gene Family in Alzheimer's Disease
Funded at Icahn School of Medicine at Mount Sinai · NIH-10915441 · Data updated 2026-11-12
This study is looking at how certain genes might affect the brain's immune system in people with Alzheimer's disease, using special techniques to learn more about how these genes work, with the hope of finding new ways to treat the condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 14, 2023 |
| Project end | August 13, 2026 |
| Funding year | 2024 |
| Award (this year) | $47,374 |
| NIH project number | 5F31AG084337-02 |
| Project ID | NIH-10915441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without genetic risk factors for the condition may not benefit from this research.
What this research studies
This research investigates the role of the MS4A gene family in Alzheimer's disease, focusing on how these genes may influence the brain's immune response. By using advanced techniques like CRISPR to edit human stem cells, the study aims to understand how variations in these genes affect microglial function, which is crucial for brain health. The research seeks to identify potential therapeutic targets that could lead to new treatments for Alzheimer's disease, a condition currently lacking effective interventions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in targeting immune responses in Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Munch, Alexandra — Icahn School of Medicine at Mount Sinai
- Study coordinator: Munch, Alexandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.