Exploring how certain factors can reverse aging in cells
Official title: Unravel the Epigenetic Mechanisms of Cellular Rejuvenation and Identify Universal Rejuvenating Transcription Factors
Funded at Vanderbilt University · NIH-10973211 · Data updated 2026-11-12
This study is exploring ways to help old cells feel young again by finding new proteins that can safely refresh them, which could lead to better treatments for aging-related health issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $34,834 |
| NIH project number | 1F99AG083284-01A1 |
| Project ID | NIH-10973211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related cellular decline or diseases associated with aging.
✕Less likely to help
Patients with conditions unrelated to cellular aging or those who are not experiencing age-related decline may not benefit from this research.
What this research studies
This research investigates the mechanisms behind cellular rejuvenation, focusing on identifying new transcription factors that can restore youthful characteristics to aged cells. The study builds on previous work with Yamanaka factors, which have shown promise in rejuvenating cells but carry risks of tumor formation. By systematically analyzing around 30 potential rejuvenating transcription factors, the research aims to understand how these factors can safely rejuvenate various types of aged cells. Patients may benefit from insights into therapies that could reverse aging processes and improve health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reverse aging in human cells, potentially improving health and longevity.
How similar studies have gone: Previous research has shown success with Yamanaka factors in animal models, but this approach seeks to identify safer alternatives, making it a novel exploration.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Han, Dongsheng — Vanderbilt University
- Study coordinator: Han, Dongsheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.