Exploring how certain chemicals modify histones to regulate gene activity in the brain
Development of a Chemical Biology Toolbox to Investigate Histone Monoaminylation
['FUNDING_OTHER'] · PURDUE UNIVERSITY · NIH-11083098
This study is looking at how a new chemical change in brain proteins, influenced by important brain chemicals like serotonin and dopamine, affects how genes work, which could help us understand brain health and development better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-11083098 on ClinicalTrials.gov |
What this research studies
This research investigates the role of histone monoaminylation, a newly identified chemical modification of histones, in regulating gene expression in the brain. By using advanced chemical biology techniques, the study aims to understand how enzymes modify histones with serotonin and dopamine, which are crucial for neuronal function. The research focuses on identifying the mechanisms by which these modifications are added, removed, and recognized by other proteins, which could have implications for understanding brain development and function in adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may be affected by conditions related to neurotransmitter imbalances or epigenetic regulation.
Not a fit: Patients with conditions unrelated to neurotransmitter function or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the regulation of gene expression in the brain, potentially impacting treatments for neurological disorders.
How similar studies have performed: While the specific focus on histone monoaminylation is novel, similar research on histone modifications has shown promising results in understanding gene regulation.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHENG, QINGFEI — PURDUE UNIVERSITY
- Study coordinator: ZHENG, QINGFEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.