Exploring how cells respond to multiple drug stimuli and their effects on health.
Understanding cascading cellular protein responses following multi-protein stimuli using network modeling and real-world evidence
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10912627
This study is looking at how different medications affect cells and how proteins in those cells interact with the drugs, with the goal of making treatments safer and more effective for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10912627 on ClinicalTrials.gov |
What this research studies
This research investigates how cells react to various drug therapies and the complex interactions that occur at the protein level. By using advanced network modeling and real-world clinical data, the study aims to understand the cascading effects of drug stimuli on cellular responses, which can lead to both beneficial outcomes and adverse drug events. The approach focuses on creating quantitative models that can predict how different proteins interact and respond to multiple drugs, ultimately improving drug design and patient safety.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are currently undergoing drug therapy for various diseases and may experience adverse drug events.
Not a fit: Patients who are not currently on any medication or those with conditions that do not involve drug therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective drug therapies by better predicting adverse effects and improving treatment outcomes.
How similar studies have performed: Previous research has shown promise in using protein-protein interaction models to understand drug effects, but this specific approach is innovative and aims to fill existing gaps in knowledge.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILSON, JENNIFER LYNN — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: WILSON, JENNIFER LYNN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.