Exploring how cells repair DNA damage and the effects on genetic stability
Understanding spontaneous mitotic crossover by single-cell multi-omics
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11086600
This study is looking at how our cells fix broken DNA, which is important for preventing issues like cancer, and it aims to find out what makes these repairs work well or go wrong, so that we can improve treatments and prevention for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11086600 on ClinicalTrials.gov |
What this research studies
This research investigates the process of homologous recombination (HR), which is crucial for repairing DNA double strand breaks that can lead to cell death or cancer. By using advanced techniques to analyze single-cell genomes, the study aims to understand the factors that influence whether DNA repair is accurate or leads to harmful genetic changes. The research focuses on identifying the types of DNA damage that trigger spontaneous HR and how these processes can affect genome integrity. Patients may benefit from insights gained into DNA repair mechanisms that could inform cancer treatment and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic predispositions to cancer or those undergoing treatment for DNA repair-related conditions.
Not a fit: Patients with conditions unrelated to DNA repair mechanisms or those not affected by genetic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of DNA repair mechanisms, potentially informing new cancer therapies and prevention strategies.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, but this approach using single-cell multi-omics is relatively novel.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YIN, YI — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: YIN, YI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers