Exploring how cells regulate iron metabolism using advanced techniques.
Official title: Understanding Ubiquitin-dependent Regulation of Iron Metabolism using Mass Spectrometry
Funded at University of California Los Angeles · NIH-11059211 · Data updated 2026-11-12
This study is looking at how a protein called FBXL5 helps control iron levels in our cells, which is important for keeping our bodies healthy, and it hopes to find new ways to treat diseases that happen when iron balance goes wrong.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $393,750 |
| NIH project number | 5R35GM153408-02 |
| Project ID | NIH-11059211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with disorders related to iron metabolism, including anemia or other related conditions.
✕Less likely to help
Patients who do not have any iron metabolism disorders or related health issues may not benefit from this research.
What this research studies
This research investigates the complex mechanisms that control iron metabolism in cells, which is crucial for various biological functions such as respiration and nutrient transport. The team employs advanced biochemistry and mass spectrometry methods to study the role of a specific protein, FBXL5, in managing iron levels within cells. By understanding these regulatory pathways, the research aims to reveal how disruptions in iron metabolism can lead to diseases, potentially paving the way for new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to iron metabolism, such as anemia and certain cancers.
How similar studies have gone: Previous research has shown promising results in understanding iron metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Wohlschlegel, James Akira — University of California Los Angeles
- Study coordinator: Wohlschlegel, James Akira
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.