Exploring how cells manage faulty RNA
Understanding the variability in nonsense-mediated RNA decay
['FUNDING_OTHER'] · UNIVERSITY OF COLORADO DENVER · NIH-10806776
This study looks at how our cells get rid of faulty RNA that can mess up gene activity, helping us understand why some bad RNAs stick around and how we might find new ways to treat related health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10806776 on ClinicalTrials.gov |
What this research studies
This research investigates how cells identify and eliminate faulty RNA molecules that can disrupt gene expression. It focuses on a process called nonsense-mediated RNA decay (NMD), which protects cells from the harmful effects of mutated RNAs. By studying how different genetic and cellular contexts affect the efficiency of NMD, the research aims to uncover the mechanisms that allow some mutated RNAs to evade destruction. This could lead to a better understanding of gene function and the potential for new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions linked to nonsense mutations.
Not a fit: Patients with conditions not related to RNA decay or nonsense mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for genetic disorders caused by nonsense mutations.
How similar studies have performed: Previous research has shown promising results in understanding RNA decay mechanisms, indicating potential for success in this area.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JAGANNATHAN, SUJATHA — UNIVERSITY OF COLORADO DENVER
- Study coordinator: JAGANNATHAN, SUJATHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.