Exploring how cell recycling affects reproduction in yeast.
Official title: Determining the roles of autophagy in gametogenesis in S. cerevisiae
Funded at Ut Southwestern Medical Center · NIH-11011416 · Data updated 2026-11-12
This study looks at how a natural recycling process in cells, called autophagy, affects the way yeast cells make reproductive cells, especially when they're under stress, to help us learn more about reproduction and cell health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | May 22, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $483,640 |
| NIH project number | 1R35GM156387-01 |
| Project ID | NIH-11011416 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of reproduction and those affected by fertility challenges.
✕Less likely to help
Patients with conditions unrelated to reproductive biology or those not experiencing fertility issues may not benefit from this research.
What this research studies
This research investigates the role of autophagy, a cellular recycling process, in the development of reproductive cells in yeast. By studying the yeast Saccharomyces cerevisiae, the research aims to understand how autophagy influences critical stages of meiosis, the process that produces gametes. The approach involves examining gene expression and cellular changes during gametogenesis, particularly under stress conditions. The findings could provide insights into the fundamental mechanisms of reproduction and cell survival.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of reproductive biology and potentially inform treatments for fertility issues.
How similar studies have gone: While the specific focus on autophagy in yeast gametogenesis is novel, similar research has shown promising results in understanding cellular processes in other organisms.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Wang, Fei — Ut Southwestern Medical Center
- Study coordinator: Wang, Fei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.