Exploring how CARD11 mutations improve immune responses against tumors
Official title: Investigating mechanisms of CARD11 mutants in enhanced anti-tumor immunity and T cell fitness (For Kathleen Cheng)
Funded at Northwestern University at Chicago · NIH-11031965 · Data updated 2026-11-12
This study is looking at how certain changes in a gene called CARD11 can help T cells become better at fighting tough solid tumors, with the hope of creating new treatments that could improve cancer care for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $44,187 |
| NIH project number | 5F30CA288003-02 |
| Project ID | NIH-11031965 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with solid tumors who may benefit from enhanced T cell therapies.
✕Less likely to help
Patients with hematological malignancies or those who do not have solid tumors may not receive benefit from this research.
What this research studies
This research investigates how specific mutations in the CARD11 gene can enhance the ability of T cells to fight tumors, particularly in solid cancers that are currently difficult to treat. By examining T cell neoplasms, the study aims to uncover genetic mechanisms that improve T cell fitness and effectiveness. The approach involves using advanced cellular therapies that leverage these mutations to boost anti-tumor immunity. Patients may benefit from new treatment strategies that could lead to better outcomes in cancer therapy.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with solid tumors, improving their chances of recovery.
How similar studies have gone: Other research has shown promising results using genetic modifications in T cells to improve cancer treatment, suggesting potential success for this approach.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Cheng, Kathleen — Northwestern University at Chicago
- Study coordinator: Cheng, Kathleen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.