Exploring how cannabis compounds can reduce pain and inflammation.
Official title: Modulation of pain mechanisms by cannabis-derived phytochemicals.
Funded at Queen's Medical Center · NIH-10990524 · Data updated 2026-11-12
This study is looking at how certain compounds from cannabis might help reduce pain and inflammation for people with chronic pain from conditions like injuries, nerve issues, cancer, or autoimmune diseases, offering a potential alternative to opioids for pain relief.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Queen's Medical Center NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | December 1, 2020 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $574,379 |
| NIH project number | 5R01AT011162-05 |
| Project ID | NIH-10990524 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing chronic pain from various conditions, such as musculoskeletal injuries, cancer, or autoimmune disorders.
✕Less likely to help
Patients who do not suffer from chronic pain or have conditions unrelated to inflammation may not benefit from this research.
What this research studies
This research investigates the potential of cannabis-derived phytochemicals to modulate pain mechanisms, particularly in patients suffering from chronic pain due to conditions like musculoskeletal injuries, neurological disorders, cancer, or autoimmune diseases. The study employs a combination of molecular and cellular signaling techniques to understand how specific cannabinoids can inhibit calcium signaling in immune cells, which may lead to reduced inflammation and pain. By identifying and characterizing the anti-inflammatory properties of these compounds, the research aims to provide alternative pain management strategies that could lessen reliance on opioids.
Why it matters
Potential benefit: If successful, this research could offer new, effective pain relief options for patients suffering from chronic pain without the risks associated with opioid use.
How similar studies have gone: Previous research has shown promising results in using cannabinoids for pain management, indicating that this approach has potential based on existing evidence.
Where this research is happening
-
Queen's Medical Center
Honolulu, United States Active
Researchers
- Principal investigator: Seto, Todd B — Queen's Medical Center
- Study coordinator: Seto, Todd B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.