Exploring how cannabinoids affect HIV in the body
Defining the impact of cannabinoids on the HIV reservoir in humanized mice
['FUNDING_OTHER'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10933510
This study is looking at how THC, a compound found in cannabis, affects HIV in mice that have human-like immune systems, to see if it can change how the virus behaves in the body, especially in the brain, which could help us understand its effects for people living with HIV.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10933510 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of cannabinoids, specifically THC, on the HIV reservoir in humanized mice. By using a controlled animal model, the study aims to understand how cannabinoid exposure influences HIV characteristics in tissues, particularly in the brain. The research will analyze various doses of THC during different stages of HIV infection and treatment, focusing on viral activity and immune responses. This approach could provide insights into the potential implications of cannabinoid use for people living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be using or considering cannabinoid therapies.
Not a fit: Patients who are not living with HIV or who do not use cannabinoids are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing HIV infection and improving treatment outcomes for patients.
How similar studies have performed: While cannabinoid use among people with HIV is common, this specific investigation into its effects on the HIV reservoir is novel and has not been extensively studied.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROWNE, EDWARD P — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: BROWNE, EDWARD P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus