Exploring how cancer treatment changes tumor characteristics in prostate cancer
Targeting Vulnerabilities Exposed by Cancer Treatment-Induced Lineage Plasticity
This study is looking at how prostate cancer cells adapt and change when treated with certain therapies, which can sometimes make the cancer harder to treat; the goal is to find ways to stop these changes so that patients with advanced prostate cancer can have better treatment results.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10885984 on NIH RePORTER |
What this research studies
This research investigates how prostate cancer cells change their characteristics in response to treatment, particularly when using androgen deprivation therapy and androgen receptor inhibitors. The study aims to understand the mechanisms behind this change, known as lineage plasticity, which can lead to treatment resistance and aggressive cancer behavior. By identifying the factors that allow these changes to occur, the researchers hope to develop new strategies that can prevent this plasticity and improve treatment outcomes for patients with advanced prostate cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with metastatic prostate cancer who are undergoing or have undergone androgen deprivation therapy.
Not a fit: Patients with localized prostate cancer or those who have not received androgen deprivation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that prolong the effectiveness of current therapies and potentially cure some advanced prostate cancers.
How similar studies have performed: Previous research has shown that targeting lineage plasticity in cancer can lead to improved treatment responses, suggesting that this approach may be promising.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Nelson, Peter S — Fred Hutchinson Cancer Center
- Study coordinator: Nelson, Peter S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.