Exploring how cancer affects fat tissue to combat weight loss in patients
Identifying the Cellular and Molecular Targets of JAK/STAT-Driven Adipose Wasting to Reverse Cancer Cachexia
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11063032
This study is looking at how cancer causes weight loss and muscle wasting, called cancer cachexia, and aims to find ways to stop this from happening, which could help patients feel better and maintain their health during treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11063032 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which cancer induces the loss of fat and muscle tissue, a condition known as cancer cachexia. By using mouse models, the study aims to identify specific cellular and molecular targets that contribute to this wasting syndrome. The researchers are particularly focused on understanding how certain signals in the body lead to fat tissue breakdown and how blocking these signals might help reverse the effects of cachexia. Patients may benefit from potential new therapies that could improve their weight and overall health during cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients experiencing significant weight loss or cachexia.
Not a fit: Patients who are not currently undergoing cancer treatment or do not exhibit symptoms of cachexia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help cancer patients maintain their weight and improve their quality of life.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in cachexia, indicating that this approach may lead to meaningful advancements.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: INFANTE, RODNEY E — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: INFANTE, RODNEY E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer associated cachexia, Cancer Cachexia, cancer induced cachexia, cancer-associated muscle wasting, cancer-induced muscle atrophy