Exploring how brain stimulation affects memory processing in humans
Using deep brain stimulation of the parietal cortex to investigate the electrophysiology of human episodic memory
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10897245
This study is looking at how a part of the brain called the parietal cortex helps us remember things, and it’s for people who are interested in understanding more about how memory works, especially with the help of special brain stimulation and medication.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10897245 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the parietal cortex in human memory by using deep brain stimulation techniques. Patients will undergo microelectrode recordings during memory tasks to identify specific types of neurons involved in memory encoding and retrieval. Additionally, the study will explore the effects of an anticholinergic agent on brain activity related to memory. The goal is to better understand the neurophysiological processes that support episodic memory.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals with memory impairments, particularly those diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients without memory impairments or those with other neurological conditions unrelated to episodic memory may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for memory-related conditions such as Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding memory processes through brain stimulation, indicating that this approach could yield valuable insights.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEGA, BRADLEY C — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: LEGA, BRADLEY C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease