Exploring how brain immune cells affect Alzheimer's disease
Understanding the protective and neuroinflammatory role of human brain immune cells in Alzheimer Disease
This study is looking at how immune cells in the brain might help or hurt people with Alzheimer's disease, hoping to find new ways to treat it by understanding these cells better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10796853 on NIH RePORTER |
What this research studies
This research investigates the role of human brain immune cells in the development and progression of Alzheimer's disease. By isolating and analyzing these cells from human brain tissue, the study aims to understand whether they contribute to protecting the brain or exacerbate neuroinflammation at different stages of the disease. The approach includes advanced techniques like single-cell RNA sequencing to capture the diverse molecular signatures of these immune cells. This could lead to insights into the mechanisms of Alzheimer's and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease at various stages.
Not a fit: Patients with other forms of dementia or cognitive impairment unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Roussos, Panagiotis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Roussos, Panagiotis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.