Exploring how brain cells contribute to nerve pain
Official title: Uncovering astrocyte contributions to neuropathic pain
Funded at Salk Institute for Biological Studies · NIH-11107378 · Data updated 2026-11-12
This study is looking at how certain brain cells called astrocytes might contribute to ongoing nerve pain, with the goal of finding better and safer treatments for people dealing with chronic pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project start | April 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $499,979 |
| NIH project number | 1R01NS142167-01 |
| Project ID | NIH-11107378 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from neuropathic pain due to nerve injury or disease.
✕Less likely to help
Patients with acute pain or those whose pain is not related to nerve injury may not benefit from this research.
What this research studies
This research investigates the role of astrocytes, a type of brain cell, in the development and persistence of neuropathic pain, which affects many individuals due to nerve injury or disease. By focusing on the spinal cord and the interactions between astrocytes and neurons, the study aims to uncover the underlying mechanisms of neuropathic pain. The researchers will utilize advanced techniques to analyze how these non-neuronal cells influence pain signaling and response. This understanding could lead to the development of safer and more effective treatments for those suffering from chronic pain.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for neuropathic pain, improving the quality of life for many patients.
How similar studies have gone: Previous research has shown promise in understanding the role of glial cells in pain mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
-
Salk Institute for Biological Studies
La Jolla, United States Active
Researchers
- Principal investigator: Nimmerjahn, Axel — Salk Institute for Biological Studies
- Study coordinator: Nimmerjahn, Axel
Related research
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Parmodulins with Low Abuse Potential for Neuropathic Pain
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.