Exploring how brain activity changes with different metabolic processes using advanced imaging techniques.
Probing the Biophysical Basis of Large-Scale Brain Dynamics Using Simultaneous PET/fMRI and EEG/PET/fMRI
This study is looking at how the brain works by using special imaging tools to see both brain activity and chemical changes, which could help us understand more about how the brain functions in healthy people and those with Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10988299 on NIH RePORTER |
What this research studies
This research investigates the dynamics of brain activity by combining advanced imaging techniques, specifically functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). By using these methods together, the study aims to overcome the limitations of fMRI alone, which can miss important metabolic and neurochemical processes. The goal is to develop a new analytical framework that links brain dynamics with metabolic changes, particularly in relation to natural arousal fluctuations. This innovative approach could provide deeper insights into the brain's functioning in both healthy individuals and those with conditions like Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with acute neurological conditions or those not diagnosed with any form of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of brain disorders, particularly Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using combined imaging techniques to enhance understanding of brain dynamics, suggesting this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Jingyuan — Massachusetts General Hospital
- Study coordinator: Chen, Jingyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.