Exploring how body clocks affect tissue healing and engineering
It Will All Get Better with Time: Circadian Rhythms in Tissue Engineering
['FUNDING_OTHER'] · UNIVERSITY OF MASSACHUSETTS AMHERST · NIH-10876396
This study is looking at how our body's natural daily rhythms can help improve treatments for conditions like diabetes and obesity by timing therapies to match these rhythms, which could lead to better healing and tissue repair.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MASSACHUSETTS AMHERST (nih funded) |
| Locations | 1 site (HADLEY, UNITED STATES) |
| Trial ID | NIH-10876396 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of circadian rhythms on tissue engineering, aiming to synchronize these biological clocks in cell cultures and during tissue regeneration. By aligning therapeutic interventions with specific times of day, the study seeks to enhance the effectiveness of treatments for conditions like diabetes and obesity, which are known to disrupt normal circadian patterns. The approach includes both in vitro synchronization of cells and in vivo restoration of rhythms at healing sites, potentially leading to improved tissue repair outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions that disrupt circadian rhythms, such as diabetes or obesity, who may benefit from improved tissue healing strategies.
Not a fit: Patients without circadian rhythm disruptions or those not requiring tissue engineering interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective tissue regeneration therapies tailored to the body's natural rhythms.
How similar studies have performed: While the concept of circadian rhythms in tissue engineering is relatively novel, there is existing evidence that timing affects drug efficacy in various diseases, suggesting potential for success in this area.
Where this research is happening
HADLEY, UNITED STATES
- UNIVERSITY OF MASSACHUSETTS AMHERST — HADLEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KEARNEY, CATHAL J — UNIVERSITY OF MASSACHUSETTS AMHERST
- Study coordinator: KEARNEY, CATHAL J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Diabetes Mellitus, Disease, Disorder