Exploring how blood vessel problems relate to Alzheimer's disease in the brain.
Official title: Understanding the mechanistic link between vascular dysfunction and Alzheimers disease-related protein accumulation in the medial temporal lobe
Funded at Massachusetts General Hospital · NIH-10906126 · Data updated 2026-11-12
This study is looking at how problems with blood vessels in the brain might make it harder for the brain to get rid of harmful proteins linked to Alzheimer's disease, helping us understand more about how these issues could lead to memory problems and possibly find new ways to treat or prevent the disease.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $123,714 |
| NIH project number | 5K99AG080134-02 |
| Project ID | NIH-10906126 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, particularly those showing signs of vascular dysfunction.
✕Less likely to help
Patients with Alzheimer's disease who do not exhibit vascular dysfunction may not benefit from this research.
What this research studies
This research investigates the connection between vascular dysfunction and the accumulation of proteins associated with Alzheimer's disease in the medial temporal lobe, a key area of the brain for memory and cognition. It focuses on understanding how small vessel disease affects the brain's ability to clear waste and maintain a healthy blood-brain barrier, which may contribute to Alzheimer's pathology. By examining these interactions, the research aims to uncover the mechanisms that link vascular issues with Alzheimer's disease, potentially leading to new insights into treatment and prevention.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has indicated that understanding the relationship between vascular health and Alzheimer's pathology can lead to significant advancements in treatment strategies.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Perosa, Valentina — Massachusetts General Hospital
- Study coordinator: Perosa, Valentina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.