Exploring how blood vessel changes affect brain aging
Understanding the role of the cerebral microvasculature in brain aging
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11087668
This study is looking at how aging affects the blood vessels in the brain and how that might lead to problems like Alzheimer's disease, using mice to explore how changes in blood flow can impact brain health and test new treatments that could help improve blood vessel function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11087668 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of aging on the brain's blood vessels and how these changes may lead to conditions like Alzheimer's disease. By using advanced imaging techniques, the study aims to understand how reduced blood flow affects the integrity of the blood-brain barrier and contributes to cognitive decline. The research will involve experiments on mice to observe the effects of simulated reduced blood flow and test potential therapies targeting mitochondrial function in blood vessels. Patients may benefit from insights gained about the relationship between vascular health and brain aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those at risk for neurodegenerative diseases.
Not a fit: Patients who are younger or do not have any cognitive impairments may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain health and prevent cognitive decline in older adults.
How similar studies have performed: Previous studies have shown promising results in understanding the role of vascular health in brain aging, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RUTKAI-GREEN, IBOLYA — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: RUTKAI-GREEN, IBOLYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.