Exploring how birds recover muscle mass after weight loss
A novel multi-omics approach to explore mechanisms of lean mass recovery
['FUNDING_OTHER'] · UNIVERSITY OF MASSACHUSETTS AMHERST · NIH-11089799
This study is looking at how migratory birds lose and regain muscle to help us understand cachexia, a condition that causes severe weight loss in people with serious illnesses like cancer and heart failure, with the hope of finding new ways to help those affected.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MASSACHUSETTS AMHERST (nih funded) |
| Locations | 1 site (HADLEY, UNITED STATES) |
| Trial ID | NIH-11089799 on ClinicalTrials.gov |
What this research studies
This research investigates cachexia, a condition causing severe weight loss and muscle wasting in terminal illnesses like cancer and heart failure. By studying migratory birds that naturally lose and quickly regain lean body mass, the research aims to uncover the biological mechanisms behind tissue regeneration. The approach combines functional assessments with advanced techniques like metabolomics and transcriptomics to understand how these birds recover from significant muscle loss. The findings could lead to new therapeutic strategies for patients suffering from cachexia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from cachexia related to conditions such as cancer, heart failure, or other chronic diseases.
Not a fit: Patients with stable weight and no signs of muscle wasting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights and treatments for patients experiencing muscle wasting due to chronic illnesses.
How similar studies have performed: Previous research on muscle recovery in animal models has shown promise, suggesting that this novel approach could yield significant insights.
Where this research is happening
HADLEY, UNITED STATES
- UNIVERSITY OF MASSACHUSETTS AMHERST — HADLEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GERSON, ALEXANDER R. — UNIVERSITY OF MASSACHUSETTS AMHERST
- Study coordinator: GERSON, ALEXANDER R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immunodeficiency Syndrome