Exploring how bacterial cell wall fragments affect immune responses
Peptidoglycan Fragment Library to Investigate Innate Immune Responses
['FUNDING_R01'] · UNIVERSITY OF DELAWARE · NIH-11165767
This study is looking at how tiny pieces of bacteria can affect our immune system, helping us understand how our body reacts to infections and inflammation, which could lead to better treatments for these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF DELAWARE (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11165767 on ClinicalTrials.gov |
What this research studies
This research investigates the role of peptidoglycan fragments, which are components of bacterial cell walls, in triggering innate immune responses. By creating a library of these fragments, the study aims to understand how different fragments interact with the immune system and influence health and inflammatory diseases. The approach involves synthesizing various peptidoglycan fragments and analyzing their effects on immune receptors and responses. This could lead to new insights into how the body responds to bacterial infections and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inflammatory diseases or those interested in understanding immune responses to bacterial infections.
Not a fit: Patients with non-inflammatory conditions or those not affected by bacterial infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for inflammatory diseases and better understanding of immune responses to bacterial infections.
How similar studies have performed: Other research has shown success in understanding immune responses to bacterial components, indicating that this approach has potential for meaningful insights.
Where this research is happening
Newark, UNITED STATES
- UNIVERSITY OF DELAWARE — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRIMES, CATHERINE LEIMKUHLER — UNIVERSITY OF DELAWARE
- Study coordinator: GRIMES, CATHERINE LEIMKUHLER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacterial disease treatment, bacterial infectious disease treatment