Exploring how bacteria transfer genetic material and develop antibiotic resistance
Biological and structural diversity of bacterial type IV secretion systems
This study is looking at how bacteria share their genes, especially the ones that help them resist antibiotics, using special tools to see how these processes work, which could help us find new ways to fight tough infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11064858 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which bacteria exchange genetic material, particularly focusing on type IV secretion systems (T4SSs) that facilitate this process. By examining the structural and biological diversity of these systems, the research aims to understand how they contribute to the spread of antibiotic resistance among bacterial populations. The study employs advanced imaging techniques, such as cryo-electron microscopy, to visualize these nanomachines and their interactions. This knowledge could lead to new strategies for combating antibiotic-resistant infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by bacterial pathogens or those who are not affected by antibiotic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to novel treatments for antibiotic-resistant bacterial infections.
How similar studies have performed: Previous research has shown success in understanding bacterial genetic exchange and antibiotic resistance mechanisms, indicating that this approach has potential for impactful findings.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Christie, Peter J. — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Christie, Peter J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.