Exploring how bacteria resist multiple antibiotics
Official title: Understanding the Molecular Rules of a Bacterial Multidrug Efflux Transporter
Funded at University of Wisconsin-Madison · NIH-11160998 · Data updated 2026-11-12
This study is looking at how some bacteria can fight off many antibiotics using special proteins, and it's for anyone interested in understanding how we might find new ways to tackle antibiotic resistance in healthcare.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $36,304 |
| NIH project number | 1F31AI186356-01A1 |
| Project ID | NIH-11160998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
What this research studies
This research investigates how certain bacteria can effectively resist a wide range of antibiotics through specialized proteins known as multidrug efflux pumps. By examining the molecular mechanisms behind these pumps, the study aims to identify how they can export various antibiotics while selectively retaining harmful substances. The approach involves creating and testing thousands of mutant versions of a specific protein to understand the factors that contribute to antibiotic resistance. This research could provide insights into new strategies for overcoming antibiotic resistance in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that enhance the effectiveness of existing antibiotics against resistant bacterial infections.
How similar studies have gone: Previous research has shown promising results in understanding antibiotic resistance mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Miller, Silas — University of Wisconsin-Madison
- Study coordinator: Miller, Silas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.