Exploring how bacteria resist multiple antibiotics
Understanding the Molecular Rules of a Bacterial Multidrug Efflux Transporter
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11160998
This study is looking at how some bacteria can fight off many antibiotics using special proteins, and it's for anyone interested in understanding how we might find new ways to tackle antibiotic resistance in healthcare.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11160998 on ClinicalTrials.gov |
What this research studies
This research investigates how certain bacteria can effectively resist a wide range of antibiotics through specialized proteins known as multidrug efflux pumps. By examining the molecular mechanisms behind these pumps, the study aims to identify how they can export various antibiotics while selectively retaining harmful substances. The approach involves creating and testing thousands of mutant versions of a specific protein to understand the factors that contribute to antibiotic resistance. This research could provide insights into new strategies for overcoming antibiotic resistance in clinical settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by antibiotic-resistant bacteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that enhance the effectiveness of existing antibiotics against resistant bacterial infections.
How similar studies have performed: Previous research has shown promising results in understanding antibiotic resistance mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MILLER, SILAS — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: MILLER, SILAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.