Exploring how arginine affects insulin production in children with type 2 diabetes
Investigation of Arginine Metabolism and Its Effects on Beta Cell Function in Children with Type 2 Diabetes
This study is looking at how a substance called arginine affects insulin production in children with type 2 diabetes, hoping to find new ways to help manage their condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10899693 on NIH RePORTER |
What this research studies
This research investigates the role of arginine metabolism in children diagnosed with type 2 diabetes (T2D), a condition that is increasingly common due to rising childhood obesity rates. The study aims to understand how arginine, an amino acid that stimulates insulin secretion, can influence the function of pancreatic beta cells in these children. By using advanced techniques like isotope tracer infusions and targeted metabolomics, researchers will assess how much arginine is available within the cells and how it affects insulin production. This could lead to new insights into managing T2D in pediatric patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with type 2 diabetes, particularly those experiencing rapid declines in beta cell function.
Not a fit: Patients without a diagnosis of type 2 diabetes or those who are not children may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children with type 2 diabetes by enhancing insulin secretion and beta cell function.
How similar studies have performed: Previous research has shown promising results in understanding the role of arginine in insulin secretion, but this specific focus on pediatric T2D is relatively novel.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Tosur, Mustafa — Baylor College of Medicine
- Study coordinator: Tosur, Mustafa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.