Exploring how arachidonic acid affects the immune environment in colorectal cancer
Interrogating the role of arachidonic acid metabolism in modulating the tumor immune microenvironment as a novel path to therapeutic intervention
This study is looking at how a fatty acid called arachidonic acid, which comes from some foods, affects the immune system in colorectal cancer, with the hope of finding better treatment options for patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10973862 on NIH RePORTER |
What this research studies
This research investigates the role of arachidonic acid, a fatty acid found in certain diets, in influencing the immune environment of colorectal cancer. By analyzing how this fatty acid and its metabolic products interact with immune cells in tumors, the study aims to uncover new therapeutic strategies. The approach includes advanced techniques like lipid profiling and single-cell RNA sequencing to understand the complex interactions within the tumor microenvironment. Patients may benefit from insights that could lead to improved cancer treatments targeting inflammation and immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with a high inflammatory response.
Not a fit: Patients with non-colorectal cancers or those not exhibiting significant immune activity in their tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that enhance immune response against colorectal cancer.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting potential for success in this novel approach.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Yeatman, Timothy J — University of South Florida
- Study coordinator: Yeatman, Timothy J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.