Exploring how arachidonic acid affects the immune environment in colorectal cancer
Official title: Interrogating the role of arachidonic acid metabolism in modulating the tumor immune microenvironment as a novel path to therapeutic intervention
Funded at University of South Florida · NIH-10973862 · Data updated 2026-11-12
This study is looking at how a fatty acid called arachidonic acid, which comes from some foods, affects the immune system in colorectal cancer, with the hope of finding better treatment options for patients.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 6, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $624,518 |
| NIH project number | 1U01CA293474-01 |
| Project ID | NIH-10973862 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer, particularly those with a high inflammatory response.
✕Less likely to help
Patients with non-colorectal cancers or those not exhibiting significant immune activity in their tumors may not benefit from this research.
What this research studies
This research investigates the role of arachidonic acid, a fatty acid found in certain diets, in influencing the immune environment of colorectal cancer. By analyzing how this fatty acid and its metabolic products interact with immune cells in tumors, the study aims to uncover new therapeutic strategies. The approach includes advanced techniques like lipid profiling and single-cell RNA sequencing to understand the complex interactions within the tumor microenvironment. Patients may benefit from insights that could lead to improved cancer treatments targeting inflammation and immune response.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that enhance immune response against colorectal cancer.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting potential for success in this novel approach.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Yeatman, Timothy J — University of South Florida
- Study coordinator: Yeatman, Timothy J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.