Exploring how APOE affects brain energy use in Alzheimer's disease
Investigating the impact of APOE on cerebral energetics
['FUNDING_R21'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10755052
This study is looking at how a specific gene called APOE might affect how our brains use energy, especially in people who are healthy but may have different levels of body fat and fatty acids, to see if these factors could be linked to early signs of Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10755052 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the APOE gene in brain energy metabolism, particularly in relation to obesity and fatty acid levels. It aims to understand how variations in the APOE genotype, especially the APOE4 allele, influence glucose transport in the brain among cognitively healthy individuals. By examining these relationships, the study seeks to uncover early metabolic changes that may contribute to the development of Alzheimer's disease. The approach involves analyzing the interactions between obesity, fatty acids, and brain function in a targeted population.
Who could benefit from this research
Good fit: Ideal candidates for this research are cognitively normal individuals who carry at least one APOE4 allele and may have a history of obesity or metabolic issues.
Not a fit: Patients who do not carry the APOE4 allele or those with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the early metabolic changes associated with Alzheimer's disease, potentially guiding future prevention strategies.
How similar studies have performed: While the specific approach of this research is novel, previous studies have indicated that understanding metabolic factors in Alzheimer's disease can lead to significant insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HWANG, JANICE JIN — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: HWANG, JANICE JIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.