Exploring how Alzheimer's disease affects behavior in older adults
Official title: Understanding the Role of Alzheimer’s Disease Pathology in Mild Behavioral Impairment
Funded at University of Michigan at Ann Arbor · NIH-11134988 · Data updated 2026-11-12
This study is looking at how changes in the brain related to Alzheimer's disease might be connected to early signs of behavior changes in older adults, and it’s for people who want to help us understand these links better by sharing their experiences and providing some health information.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $128,520 |
| NIH project number | 1K01AG086617-01A1 |
| Project ID | NIH-11134988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing mild behavioral changes that may indicate early signs of Alzheimer's disease.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any behavioral symptoms may not benefit from this research.
What this research studies
This research investigates the relationship between Alzheimer's disease pathology and mild behavioral impairment (MBI) in older adults. It aims to understand how neuropsychiatric symptoms, often seen before dementia, may be linked to changes in brain networks rather than just memory loss. By using a standardized framework to assess these symptoms, the study will explore the underlying neural mechanisms and their connection to Alzheimer's disease biomarkers. Patients may undergo assessments and provide blood samples to help identify these relationships.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promising results in understanding the links between behavioral symptoms and Alzheimer's pathology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Iordan, Alexandru Daniel — University of Michigan at Ann Arbor
- Study coordinator: Iordan, Alexandru Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.