Exploring how air pollution affects Alzheimer's disease and related dementias
Official title: IMPACT-ADRD: Investigating the Multi-omics Perturbations Associated with Complex Environmental Toxicants and their Contribution to Alzheimer's Disease and Related Dementias
Funded at Emory University · NIH-10972892 · Data updated 2026-11-12
This study is looking at how air pollution, especially tiny particles in the air, might increase the chances of getting Alzheimer's and other types of dementia, and it's for anyone interested in understanding how our environment can affect brain health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $2,278,304 |
| NIH project number | 1U01AG088425-01 |
| Project ID | NIH-10972892 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease or related dementias, particularly those with a history of exposure to air pollution.
✕Less likely to help
Patients who do not have any risk factors for Alzheimer's disease or related dementias may not benefit from this research.
What this research studies
This research investigates the relationship between exposure to air pollution, specifically fine particulate matter (PM2.5), and the risk of developing Alzheimer's disease and related dementias. By analyzing various components of PM2.5, such as metals and organic carbon, the study aims to uncover the biological mechanisms that link these pollutants to neurotoxicity. The research employs advanced molecular profiling techniques to assess changes in blood, cerebrospinal fluid, and brain tissue, providing insights into how environmental factors contribute to these chronic conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for Alzheimer's disease and related dementias, potentially reducing their incidence.
How similar studies have gone: Previous studies have shown promising results using omics approaches to understand environmental health impacts, suggesting potential for success in this novel investigation.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Huels, Anke — Emory University
- Study coordinator: Huels, Anke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.