Exploring how aging and social factors affect dementia in older adults
Immunosenescence, socioeconomic disadvantage and dementia in the US aging population
['FUNDING_R01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10980531
This study is looking at how aging in the immune system and social factors like income and race can affect the risk of memory problems and Alzheimer's in older adults, using data from a diverse group of people across the U.S. to help find ways to prevent these issues in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10980531 on ClinicalTrials.gov |
What this research studies
This research investigates the biological processes that contribute to cognitive decline and Alzheimer's Disease and related dementias (ADRD) in older adults. By focusing on peripheral immunosenescence, the study aims to understand how immune system aging interacts with social factors like socioeconomic status and race/ethnicity to influence dementia risk. The research will utilize longitudinal data from a diverse sample of older adults across the U.S. to establish connections between these factors and cognitive health outcomes. This approach seeks to fill gaps in current knowledge and inform future prevention strategies for ADRD.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 21 years old, who may be at risk for cognitive decline or dementia due to age or socioeconomic factors.
Not a fit: Patients who are younger than 21 or do not have any risk factors for cognitive decline or dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for dementia, potentially benefiting millions of older adults.
How similar studies have performed: Previous research has shown promising results in understanding the links between immune aging and cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOPPERT, GRACE A — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: NOPPERT, GRACE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus