Exploring how aging and inflammation contribute to blood cancer development
Assessing the Interplay Between Inflammatory Signaling and Epigenetic Dysregulation in Age-associated Clonal Hematopoiesis and Leukemia Initiation
This study is looking at how getting older and inflammation might increase the risk of developing acute myeloid leukemia (AML) by examining changes in blood stem cells, and it hopes to find new ways to prevent or treat this type of blood cancer that could help patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-10906755 on NIH RePORTER |
What this research studies
This research investigates the relationship between aging, inflammation, and the development of acute myeloid leukemia (AML). It focuses on how age-related changes in the blood system, particularly mutations in blood stem cells, can lead to an increased risk of cancer. By studying these mutations and their effects on cell behavior, the research aims to uncover the mechanisms that drive the transformation from clonal hematopoiesis to leukemia. Patients may benefit from insights that could lead to new prevention or treatment strategies for blood cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 45 and above, who may be at risk for blood cancers.
Not a fit: Patients who are younger than 45 or do not have any risk factors for blood cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for age-related blood cancers like AML.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammation and genetic mutations in cancer development, suggesting that this approach could yield valuable insights.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Trowbridge, Jennifer Jean — Jackson Laboratory
- Study coordinator: Trowbridge, Jennifer Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.