Exploring how aging and genetics affect lung cancer development
Dissecting the interplay between aging, genotype and the microenvironment in lung cancer
This study is looking at how getting older and our genes can affect the way lung cancer develops, using special mouse models to help us learn more about how age impacts tumor growth, especially for older adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10906752 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between aging, genetic factors, and the microenvironment in the development of lung cancer. By using advanced genetically engineered mouse models and CRISPR technology, the study aims to understand how age-related changes influence tumor initiation and growth. The researchers will analyze the effects of various genetic alterations on cancer progression, providing insights into the mechanisms that drive lung cancer in older adults. This approach combines innovative techniques to enhance the precision of cancer modeling and improve our understanding of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who are at higher risk for lung cancer.
Not a fit: Patients under the age of 65 or those without a genetic predisposition to lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating lung cancer in older patients.
How similar studies have performed: Previous research has shown promise in using genetically engineered models and CRISPR technology to study cancer, indicating that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Winslow, Monte Meier — Stanford University
- Study coordinator: Winslow, Monte Meier
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.