Exploring how aging and Alzheimer's disease affect brain cell growth and function
Development of novel genomic approaches for profiling cellular temporal-spatial dynamics of neurogenesis in Aging and Alzheimer's disease
This study is looking at how new brain cells are made and how this process changes as we get older or develop Alzheimer's, with the goal of finding ways to keep our brains healthy as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11054613 on NIH RePORTER |
What this research studies
This research investigates the processes of adult neurogenesis, which is the formation of new brain cells, and how these processes are altered in aging and Alzheimer's disease. By developing a novel high-throughput genomics approach, the study aims to map the molecular dynamics of neurogenesis at a single-cell level in both human and mouse brains. This will help researchers understand the abnormal cell states that arise during aging and neurodegenerative diseases, potentially leading to new insights into treatment strategies. Patients may benefit from advancements in understanding how to promote healthy brain function as they age.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with neurological conditions unrelated to aging or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing brain health and combating Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using advanced genomics to study neurogenesis, making this approach both innovative and building on prior successes.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Cao, Junyue — Rockefeller University
- Study coordinator: Cao, Junyue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.