Exploring how aging affects the support system for intestinal stem cells
Understanding the role of the stromal cell niche in intestinal stem cell aging
['FUNDING_CAREER'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-10889912
This study looks at how getting older affects the special cells that help keep your gut healthy, focusing on a protein called RSPO3, to see if changes in this protein might explain why gut health can decline with age, which could lead to new ways to support gut health as we grow older.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10889912 on ClinicalTrials.gov |
What this research studies
This research investigates how aging impacts the stromal cell niche that supports intestinal stem cells (ISCs), which are crucial for maintaining gut health. The study focuses on a specific protein, RSPO3, produced by stromal cells, and how its levels change with age. By using advanced mouse models and co-culture systems, researchers aim to understand the decline in the function of these supportive cells in older individuals. The findings could reveal new insights into the mechanisms of aging and potential interventions to enhance ISC function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may experience age-related decline in gut health.
Not a fit: Patients under the age of 65 or those without age-related gut health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving gut health and function in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of stromal cells in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GOTO, NORIHIRO — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: GOTO, NORIHIRO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.