Exploring how adrenal gland tissues develop and function in health and disease
Official title: Using 2D and 3D adrenal gland tissues to investigate developmental and disease paradigms
Funded at University of Georgia · NIH-11138288 · Data updated 2026-11-12
This study is exploring how adrenal gland tissues grow and work using special lab models made from human stem cells, with the goal of finding better ways to understand and treat adrenal disorders like adrenal insufficiency and congenital adrenal hyperplasia, which could help patients manage their hormone levels more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | May 6, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $718,499 |
| NIH project number | 1R01HD115812-01A1 |
| Project ID | NIH-11138288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with adrenal gland disorders, such as adrenal insufficiency or congenital adrenal hyperplasia.
✕Less likely to help
Patients without adrenal gland disorders or those who do not have a genetic predisposition to such conditions may not benefit from this research.
What this research studies
This research investigates the development and function of adrenal gland tissues using advanced 2D and 3D models derived from human pluripotent stem cells. By examining the interactions between different cell types within the adrenal glands, the study aims to uncover the underlying mechanisms of adrenal disorders and their treatments. Patients may benefit from insights gained about hormone regulation and potential new therapies for conditions like adrenal insufficiency and congenital adrenal hyperplasia. The research employs co-culture systems to identify signaling molecules that influence adrenal gland function.
Why it matters
Potential benefit: If successful, this research could lead to novel treatment options for patients with adrenal gland disorders.
How similar studies have gone: Other research has shown promise in using 3D modeling to study organ development and disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Zeltner, Nadja — University of Georgia
- Study coordinator: Zeltner, Nadja
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.