Exploring how abnormal R-loop formation affects DNA stability
Investigating the connection between aberrant R-loop formation and genome instability
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10915439
This study is looking at how certain structures called R-loops can cause problems in our DNA, which might lead to diseases like cancer and neurological disorders, and it aims to find ways to break down the harmful ones to help develop better treatments for patients.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10915439 on ClinicalTrials.gov |
What this research studies
This research investigates the formation of R-loops, which are structures that occur when RNA binds to DNA, potentially leading to DNA damage and instability. The study aims to differentiate between normal and harmful R-loops and understand how they contribute to conditions like cancer and neurological diseases. By examining the role of specific enzymes that degrade these harmful structures, the research seeks to uncover mechanisms that could prevent DNA damage. Patients may benefit from insights that could lead to new treatments for diseases associated with genome instability.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic predispositions to cancer or neurological diseases linked to DNA instability.
Not a fit: Patients with conditions unrelated to DNA damage or genome instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing DNA damage in patients with cancer or neurological disorders.
How similar studies have performed: Other research has shown promising results in understanding R-loops and their impact on genome stability, suggesting that this approach has potential for significant breakthroughs.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VIERA, TALYSA C — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: VIERA, TALYSA C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers