Exploring how a specific protein modification affects brain development and autism.
Understanding the Role of Histone Ubiquitination in Plasticity and Neurodevelopmental Disease
This study is looking at how a specific protein in the brain might be linked to autism and other developmental disorders, hoping to understand how changes in certain genes can affect brain function and development.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10995404 on NIH RePORTER |
What this research studies
This research investigates the role of histone H2B ubiquitination in the brain, particularly its connection to autism and other neurodevelopmental disorders. By studying the functions of genes involved in epigenetic regulation, the project aims to uncover how disruptions in these genes can lead to brain dysfunction. The research focuses on a specific adapter protein linked to a syndrome that affects neurological development, aiming to understand its role in gene regulation during brain plasticity and development. Through this work, the researchers hope to provide insights into the molecular mechanisms underlying these disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with autism or related neurodevelopmental disorders, particularly those with genetic mutations affecting epigenetic factors.
Not a fit: Patients without neurodevelopmental disorders or those whose conditions are unrelated to epigenetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the biological mechanisms behind autism and related disorders, potentially informing new treatment strategies.
How similar studies have performed: While the specific focus on histone H2B ubiquitination in relation to neurodevelopmental disorders is relatively novel, previous studies have shown promising results in understanding epigenetic factors in brain function.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Erickson, Alyssa a — Washington University
- Study coordinator: Erickson, Alyssa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.