Exploring how a specific protein helps poxviruses spread inside the body
Official title: Understanding the Function of F13 as a Matrix Protein for Poxvirus Intracellular Envelopment
Funded at University of Rochester · NIH-11004695 · Data updated 2026-11-12
This study is looking at how a protein called F13 helps poxviruses, which can cause serious illnesses, move around and spread inside human cells, and it's important for understanding how these viruses might affect us, especially in the context of potential outbreaks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | February 10, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $373,450 |
| NIH project number | 5R01AI168023-03 |
| Project ID | NIH-11004695 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who may be at risk for infections from poxviruses, including healthcare workers and those in close contact with infected individuals.
✕Less likely to help
Patients who are not at risk for poxvirus infections or those with no history of exposure to these viruses may not benefit from this research.
What this research studies
This research investigates the role of a protein called F13 in the process by which poxviruses, including those that can cause serious diseases, envelop and transport themselves within human cells. The study aims to understand how this protein interacts with other viral components to facilitate the virus's ability to spread and cause infection. By using advanced molecular techniques, researchers will analyze the mechanisms of viral envelopment and its implications for disease transmission. This work is particularly relevant given the potential threat of poxviruses in biological attacks and emerging infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating infections caused by poxviruses.
How similar studies have gone: Previous research has shown promise in understanding viral mechanisms similar to those being investigated in this study, indicating a potential for significant advancements in the field.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Ward, Brian M — University of Rochester
- Study coordinator: Ward, Brian M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.