Exploring how a specific protein affects sugar modifications in cells related to Alzheimer's disease
Understanding the mechanism of adaptor protein engagement by OGT and its functional effects on glycosylation
['FUNDING_R15'] · ST. OLAF COLLEGE · NIH-10513912
This study is looking at how a protein called OGT helps attach sugar molecules to other proteins, which is important for how our cells work, and it's especially focused on understanding how this process might affect diseases like Alzheimer's and cancer, with the hope of finding new ways to treat patients.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. OLAF COLLEGE (nih funded) |
| Locations | 1 site (NORTHFIELD, UNITED STATES) |
| Trial ID | NIH-10513912 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a protein called O-GlcNAc transferase (OGT) in modifying other proteins with sugar molecules, which is crucial for various cellular functions. The study aims to understand how OGT selects its protein targets and how this selection impacts diseases like Alzheimer's and cancer. By examining the mechanisms of OGT's interactions with adaptor proteins, the research seeks to uncover potential therapeutic strategies to regulate these modifications, which could lead to better treatments for patients. The approach involves detailed biochemical assays and analysis of protein interactions in cellular environments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other conditions linked to protein misregulation.
How similar studies have performed: Previous research has shown promising results in understanding protein modifications and their implications in diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
NORTHFIELD, UNITED STATES
- ST. OLAF COLLEGE — NORTHFIELD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOINER, CASSANDRA MARIE — ST. OLAF COLLEGE
- Study coordinator: JOINER, CASSANDRA MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease