Exploring how a specific protein affects early embryo development and birth defects.
Official title: Investigation of the serine protease Masp1 as a novel regulator of Bmp signaling during early embryonic development.
Funded at Idaho State University · NIH-10974741 · Data updated 2026-11-12
This study is looking at a protein called Masp1 to see how it affects early development in embryos, which could help us understand and prevent birth defects, especially for conditions like 3MC Syndrome.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Idaho State University NIH-funded |
| Lab location | 1 site (Pocatello, United States) |
| Project start | August 7, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $415,376 |
| NIH project number | 1R15HD112869-01A1 |
| Project ID | NIH-10974741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations associated with developmental disorders, particularly those related to 3MC Syndrome.
✕Less likely to help
Patients without genetic mutations affecting embryonic development or those not related to the conditions studied may not benefit from this research.
What this research studies
This research investigates the role of a protein called Masp1 in early embryonic development, particularly how it may influence the formation of structures that can lead to birth defects. By studying the effects of Masp1 in embryos of the African Clawed Frog, researchers aim to understand how genetic changes can disrupt normal development. The project focuses on identifying the molecular functions of Masp1 and its interaction with the BMP signaling pathway, which is crucial for proper tissue formation. The findings could provide insights into potential clinical interventions for conditions like 3MC Syndrome.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for birth defects caused by genetic mutations.
How similar studies have gone: While the specific focus on Masp1 is novel, similar research has shown success in understanding genetic influences on embryonic development and associated birth defects.
Where this research is happening
-
Idaho State University
Pocatello, United States Active
Researchers
- Principal investigator: Ray, Heather Joy — Idaho State University
- Study coordinator: Ray, Heather Joy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.