Exploring how a specific genetic factor in mothers may protect against cleft palate in babies
Official title: Investigating the protective effect of maternal Thm1 heterozygosity against cleft palate
Funded at University of Kansas Medical Center · NIH-10871838 · Data updated 2026-11-12
This study is looking at how a specific gene in mothers might help prevent cleft palate in their babies, using mice to learn more about how genetics can play a role in this common birth defect.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $193,750 |
| NIH project number | 5R21DE032515-02 |
| Project ID | NIH-10871838 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be expectant mothers with a family history of cleft palate or related genetic conditions.
✕Less likely to help
Patients who do not have a family history of cleft palate or congenital craniofacial anomalies may not receive direct benefits from this research.
What this research studies
This research investigates the role of maternal genetics in preventing cleft palate, a common birth defect. By studying mouse models, the researchers aim to understand how certain genetic variations in mothers can influence the likelihood of their offspring developing this condition. The study focuses on the Thm1 gene and its potential protective effects during the development of the palate. If successful, this research could lead to new insights into genetic factors that contribute to craniofacial anomalies.
Why it matters
Potential benefit: If successful, this research could provide new strategies for preventing cleft palate in newborns.
How similar studies have gone: While there has been significant research on environmental factors affecting cleft palate, this investigation into maternal genetic protection is novel and has not been extensively studied.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Saadi, Irfan — University of Kansas Medical Center
- Study coordinator: Saadi, Irfan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.