Exploring how a specific enzyme can improve cancer therapy and immune responses
Discovery of Chemical Probes of SAMHD1 for Modulation of Cancer Therapy and the Immune System
This study is looking at a special enzyme called SAMHD1 to see how it affects cancer treatment and the immune system, with the goal of finding new medicines that could make cancer therapies work better for patients with tough-to-treat tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10650716 on NIH RePORTER |
What this research studies
This research investigates the enzyme SAMHD1, which plays a crucial role in regulating DNA and RNA within cells. By understanding how SAMHD1 contributes to cancer drug resistance and immune responses, the researchers aim to develop small molecule inhibitors that can enhance the effectiveness of cancer treatments. The study employs advanced techniques like high-throughput screening to identify potential compounds that can modulate SAMHD1's activity. Patients may benefit from improved cancer therapies that are more effective against resistant tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that exhibit resistance to nucleoside anticancer drugs.
Not a fit: Patients with cancers that do not involve SAMHD1-related drug resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that overcome drug resistance and enhance immune responses.
How similar studies have performed: Other research has shown promise in targeting similar pathways for enhancing cancer treatment, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Stivers, James T. — Johns Hopkins University
- Study coordinator: Stivers, James T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.