Exploring how a special fish survives extreme stress conditions
Official title: Stress tolerant annual killifish: a new model for the cellular stress response
Funded at Brigham and Women's Hospital · NIH-10793543 · Data updated 2026-11-12
This study is looking at a special fish that can survive tough environments to learn how our cells handle stress, which might help develop new treatments for diseases related to cellular stress.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 22, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $125,000 |
| NIH project number | 5K99GM148723-02 |
| Project ID | NIH-10793543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to cellular stress, such as neurodegenerative diseases or cancer.
✕Less likely to help
Patients with conditions unrelated to cellular stress responses may not receive any benefit from this research.
What this research studies
This research investigates how the annual killifish, known for its ability to withstand harsh environmental conditions, can provide insights into cellular stress responses. By studying this fish, researchers aim to understand how cells manage stress by regulating gene expression and utilizing specific cellular structures called stress granules. The project focuses on the role of small non-coding RNAs in this process, which could lead to new therapeutic approaches for various diseases. Patients may benefit from the findings as they could inform treatments for conditions related to cellular stress.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies for diseases caused by cellular stress responses.
How similar studies have gone: Other research has shown promise in using model organisms to understand cellular stress responses, indicating that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Riggs, Claire L — Brigham and Women's Hospital
- Study coordinator: Riggs, Claire L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.