Exploring how a new DNA sequence pattern affects protein interactions with nucleosomes
Official title: Uncovering the role of a new DNA sequence pattern in nucleosome-protein interactions
Funded at Rochester Institute of Technology · NIH-10628145 · Data updated 2026-11-12
This study is exploring how certain patterns in DNA help proteins attach to it, which is important for controlling genes, and the findings could help us better understand genetic diseases that affect patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rochester Institute of Technology NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | May 5, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $444,000 |
| NIH project number | 1R15GM149587-01 |
| Project ID | NIH-10628145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic conditions linked to transcription factor dysfunction or chromatin structure abnormalities.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or chromatin interactions may not receive any benefit from this research.
What this research studies
This research investigates the interactions between transcription factors and nucleosomes, focusing on a newly identified DNA sequence pattern. It aims to understand how these sequences influence the binding of proteins to DNA, particularly looking at the structural roles of specific dinucleotides in nucleosomal DNA. By analyzing the periodic patterns of these sequences, the study seeks to uncover the mechanisms that govern protein-DNA interactions, which are crucial for gene regulation. Patients may benefit from insights gained in this research that could lead to advancements in understanding genetic diseases.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of gene regulation and potentially lead to new therapeutic strategies for genetic disorders.
How similar studies have gone: While the specific approach of investigating the anti-WW/SS pattern in nucleosomes is relatively novel, previous studies have successfully explored transcription factor interactions with nucleosomes, indicating potential for meaningful findings.
Where this research is happening
-
Rochester Institute of Technology
Rochester, United States Active
Researchers
- Principal investigator: Cui, Feng — Rochester Institute of Technology
- Study coordinator: Cui, Feng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.